Use of Design of Experiments to define Manufacturing Process Conditions for an ADC

Time: 11:30 am
day: day 1 track 4 am


This presentation will describe
the use of design of experiments
(DOE) to understand the impact
of process parameters at the
reactive stages on an ADC
product quality attributes. A
2^4 full factorial design was
performed and the results were
analysed via the MODDE®
software, with Drug to Antibody
ratio (DAR) results shown. The
software enabled identification
of safe manufacturing set points
for the process parameters.