Douglas A Levine

Douglas A Levine

Company: Merck Research Labs

Job title: Senior Principal Scientist, Early Oncology Development


ROR1 Targeting with the Antibody Drug-Conjugate MK-2140 in Aggressive Non-Hodgkins Lymphoma 5:00 pm

Discussing how Receptor tyrosine kinase-like orphan receptor 1 (ROR1) represents an attractive, cancer-specific, cellsurface target for antibody-based therapies MK-2140 is a novel antibody-drug conjugate (ADC) that binds to an external ROR1 epitope and rapidly internalizes to deliver monomethyl auristatin E (MMAE) to tumor cells Evaluating how this Phase 1 dose-ranging study provides the first clinical…Read more

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