Ruud Coumans

Ruud Coumans

Company: Byondis

Job title: Project Leader Antibody-Drug Conjugates


ByonShieLD® – A Platform for the Generation of Site-Specific Antibody– Drug Conjugates That Allows for Selective Reduction of Engineered Cysteines 12:00 pm

• Identifying optimal sites for conjugating a hydrophobic payload through use of an in silico screening procedure • Compared to randomly conjugated ADCs, the sitespecific ADCs were less hydrophobic and had better efficacy and exposure in an in vivo xenograft model • Discussing how site-specific ADCs can be manufactured using a newly discovered selective reducing…Read more

day: day 1 track 1 am

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