Anton Kozyryev
Senior Scientist Merck & Co.
Seminars
Monday 3rd November 2025
Laying Out the Strategy for Analytical Method Selection for Charge Variants Across High DAR ADCs
10:30 am
- Highlighting stability challenges with ADC icIEF analysis caused by cytotoxic payload hydrolysis at specific pH
- Exploring how On-Board Mixing (OBM) enhances ADC sample stability with immediate sample mixing before analysis
- Supporting potential use of Capillary Zone Electrophoresis as a backup method for charge variant analysis, especially where OBM is not feasible, to enhance the analytical toolkit
