Daniel Calarese
Senior Director, Innovation & Strategy Sutro Biopharma
Seminars
Wednesday 5th November 2025
The Way Forward: What’s the New Path to the Next-Generation of ADCs?
12:30 pm
- Understanding how to migrate from non-selective ADC payloads
- Debating the right properties for a next generation payload and linker: Can (or should?) any small molecule therapeutic be developed into an ADC?
- Debating the right strategy for dual-payload ADCs
- Understanding ADC toxicity and developability for next-generation conjugates
Monday 3rd November 2025
Showcasing Development of Site-Specific, High-DAR Dual-Payload ADCs
12:00 pm
- Addressing the clinical challenge of acquired resistance to single-payload ADCs by delivering two different payloads simultaneously to tumors
- Utilizing an innovative cell-free platform to create novel dual payload conjugates
- Showcasing dual-payload ADC approaches with superior preclinical in vitro and in vivo efficacy data
