Michael Lucas
Senior Scientist Abbvie
Seminars
Monday 3rd November 2025
Developing a Scaled- Down Freeze/Thaw Model for ADCs & Evaluating Impact on Potential CQAs
10:30 am
- Exploring drug substance freeze and thaw rates to mimic at-scale processes and analyzing how these influence potential CQAs
- Assessing evolution of the freeze/thaw process to determine process parameters that impact protein stability
- Quantifying pH drifts during freeze/thaw of ADCs in a scaled down model
