Xiaoxia Gong
Senior Scientist Bristol Myers Squibb
Seminars
Tuesday 4th November 2025
Understanding HIC Analysis of Low DAR ADCs to Identify Contributing Positional Isomers or Payload Hydrolysis
3:00 pm
- Carrying out HIC of low DAR ADCs and identifying multiple peaks indicative of potential positional isomers
- Fractioning HIC peaks and conducting further analysis to identify root causes
- Explaining characterization to identify ADC payload hydrolysis and understanding impact on product quality
