Evaluating Engineering of Protein-Drug Conjugates for Balanced Cellular Uptake & Solid Tumor Penetration
- Examining unique delivery challenges encountered for solid tumor ADCs that may result in a binding-site barrier
- Investigating how mechanistic modeling, supported by quantitative experimental parameters, can inform on ideal drug design to overcome these challenges
- Focusing on how intentional protein-drug conjugate design can improve tumor penetration to expose the greatest number of tumor cells to a therapeutic concentration of payload