Modeling ADC Payload Biology Using Simulated Cells
- Presenting a cell signaling network-based computational model of cytotoxic payload response across diverse molecular contexts
- Showcasing predicted response results from test samples across cancer subtypes, including examples with SLFN11 and SN38- Prexasertib
- Demonstrating the value of cell simulations to predict drug perturbations and reveal mechanistic insights to guide ADC discovery