Modeling ADC Payload Biology Using Simulated Cells

  • Presenting a cell signaling network-based computational model of cytotoxic payload response across diverse molecular contexts
  • Showcasing predicted response results from test samples across cancer subtypes, including examples with SLFN11 and SN38- Prexasertib
  • Demonstrating the value of cell simulations to predict drug perturbations and reveal mechanistic insights to guide ADC discovery