TME-Specific Payload Release: Exploring Discovery & Preclinical Validation of a Novel Enzyme-Cleavable Linker
- Addressing challenges of tumor heterogeneity and poor drug penetration of solid tumors with internalization-independent payload release
- Screening and identifying a unique linker using a specific TME enzyme consistently expressed across cancer models for next-generation ADC development
- Achieving superior efficacy and safety with an internalization-independent linker-payload system in ductal carcinoma and squamous carcinoma cell lines