Doug Kline
Senior Scientist II Abbvie
Doug Kline received his PhD in immunology from the University of Chicago and is currently a Senior Scientist at AbbVie in Oncology Discovery. His research focuses on the interplay between tumor-intrinsic regulated cell death pathways and the subsequent host immune responses, with particular interest in understanding the role of immune cell engagement in the MOA of tumor targeting ADCs.
Seminars
Monday 12th October 2026
Assessing Immunogenic Senescence to Promote the Activity of Topo1 Inhibitor ADCs
2:00 pm
- Exploring how Topo1 and Topo1-ADCs elicit immunogenic cell stress in vivo through the induction of cellular senescence
- Delineating the host immune cell requirements for Topo1-induced immunogenicity
- Identifying biomarkers of immunogenic cell stress mediated by Topo1 ADCs
