Ha Le
Senior Scientist, Biologics Analytical R&D Merck & Co
Seminars
Monday 12th October 2026
Evaluating Environmental Temperature as a Hidden Critical Factor in icIEF for a Late-Stage ADC
2:30 pm
- Explaining how method validation failures revealed environmental temperature as an overlooked driver of icIEF performance during method development
- Small increases in ambient temperature disrupt separation, impacting ADC charge variant profiling and data reliability
- Defining a controlled temperature window to enable robust, transferable icIEF performance across sites and instruments for a late-stage ADC
