Jay Mettetal
In Vitro Oncology Bioscience Head (US) AstraZeneca
Seminars
Monday 3rd November 2025
Evaluating Mechanisms of ADC Drug Resistance & Strategies of Rational & Orthogonal Combinations to Improve Outcomes
1:30 pm
- Understanding the role of antigen and payload-mediated resistance mechanisms
- Laying out considerations of how cellular heterogeneity can contribute to ADC resistance
- Exploring examples of how mechanistic and orthogonal combinations can be applied towards improving ADC activity
