Jingwen Ding

Senior Technical Product Manager SCIEX

Monday 3rd November 2025

Laying Out Comprehensive Characterization of a Cys-Linked ADC Using Enhanced Native MS, Middle-Down MS & Peptide Mapping Workflows

12:00 pm

Highlighting the benefits of novel QTOF system with improved MS sensitivity using intact/native MS, subunit/middle-down MS and peptide mapping workflows in Cys-linked ADC, whilst reducing sample consumption
Utilizing enhanced peptide mapping workflow with electron-activated dissociation to provide confident characterization across antibody sequence coverage, low-abundance impurities, PTM/payload localization, disulfide bond mapping and amino acid isomer differentiation
Exploring intuitive tools for streamlined data analysis using a software package specifically designed for biotherapeutic characterization