Jingzhou Wang
Associate Principal Scientist, Discovery Chemistry Merck & Co
Jingzhou Wang is an Associate Principal Scientist at Merck & Co., where he specializes in computational structural biology and its application to drug discovery. His work focuses on integrating computational and experimental (“wet/dry lab”) approaches to advance the design and optimization of complex therapeutics, including ADCs. Jingzhou has contributed to innovations in structural and molecular engineering to improve targeting, stability, and efficacy in next generation bioconjugates. With a strong background in computational biology and protein design, he brings a multidisciplinary perspective to accelerating the development of novel medicines.
Seminars
- Laying out experimental work to develop a novel conjugation method utilizing chemoselective reduction of engineered cysteines, with broad site-specific conjugation applicability
- Utilizing computational modeling to visualize conjugation sites shielded during circulation
- Identifying optimized conjugation sites by combining insights from x-ray crystallography structures