Johanna Midelet
Director - Bioconjugation & Chemistry Abzena
Seminars
Tuesday 13th October 2026
Improving the Delivery of Next-Generation ADCs with ThioBridge Site-Specific Conjugation Technology
11:30 am
- Delving into mechanistic insights of ThioBridge and advantages over conventional stochastic conjugation approaches, demonstrated through in vitro and in vivo ADC stability data
- Exploring how DAR can be precisely controlled using ThioBridge to optimize ADC therapeutic activity
- Assessing design strategies for optimizing linker-payload combinations to improve in vivo efficacy, supported by relevant preclinical data
- Manufacturing Considerations: Understanding key aspects of ThioBridge linker-payload and ADC manufacturing processes
