Josh Xiao
Chief Scientific Officer Nona Biosciences
Seminars
Tuesday 13th October 2026
Beyond Internalization: A Novel Tumor Microenvironment Protease-Cleavable Linker & Topo1 Payload for Next-Generation ADCs
11:30 am
- Developing a hydrophilic IntraExo-Release linker-payload employing a dual approach to release payload in the TME and inside cancer cells
- Describing proprietary linker cleavage by a TME-upregulated protease or an intracellular protease, with demonstrated superior preclinical efficacy in mouse tumor models
- Combining Nona’s IntraExo linker-payload technology with fully human IgG antibodies and VH only antibodies from H2L2 and HCAb Harbour Mice® to drive superior tumor engagement and improve therapeutic outcomes
