Kai Ni
Staff Engineer Takeda Pharmaceutical
Seminars
Wednesday 14th October 2026
Presentation Preview: Developing an On-Column Capping Approach to Reduce Charge Heterogeneity of THIOMAB ADCs
- Highlighting two examples of mAb intermediates with high charge heterogeneity, raising regulatory concerns
- Developing on-column capping approach to mask engineered thiols under redox conditions and reduce capping heterogeneity
- Expanding universal implementation of capping approach to reduce ADC analytical complexity and improve process control
