Kai Ni
Staff Engineer, Biotherapeutics Process Development Takeda Pharmaceutical
Kai Ni serves as a Staff Engineer in Biotherapeutics Process Development (Downstream) at Takeda. His experience spans preclinical, early- and late-stage clinical pipeline management, and process development across multiple modalities. He has expertise in purification and bioconjugation, and has led cross-functional, multi-site collaborations supporting pipeline programs, technical development, and strategic process initiatives.
Seminars
Wednesday 14th October 2026
Developing an On-Column Capping Approach to Reduce Charge Heterogeneity of THIOMAB ADCs
2:00 pm
- Highlighting two examples of mAb intermediates with high charge heterogeneity, raising regulatory concerns
- Developing on-column capping approach to mask engineered thiols under redox conditions and reduce capping heterogeneity
- Expanding universal implementation of capping approach to reduce ADC analytical complexity and improve process control
