Konstantin Piatkov
Associate Director, DMPK & Modeling Takeda Pharmaceutical
Konstantin Piatkov is a DMPK and Modeling Lead at Takeda Pharmaceuticals, where he drives DMPK strategy for oncology and autoimmune therapies through translational science and quantitative approaches. In his current role, he integrates preclinical and clinical data to inform biomarker strategies, PK/PD modeling, and first-in-human dose selection for complex modalities, including ADCs and cell and gene therapies. Konstantin brings deep expertise in immuno-oncology, translational biomarkers, PK/PD modeling, and immunogenicity, supporting the translation of innovative therapeutics from discovery into the clinic.
Seminars
Wednesday 14th October 2026
Beyond Allometry: Assessing Translational PK/PD Modeling for Human Projection of a Nonlinear Immune Cell Directed ADC
2:30 pm
- Highlighting the translational uncertainty of nonlinear, target mediated ADC PK in first-in human prediction
- Integrating preclinical ADC data and clinical data points from parental antibody to improve accuracy of translation
- Leveraging population PK/RO simulations to inform TAK-500 human exposure, receptor occupancy, and pharmacologically active dose selection
