Konstantin Piatkov
Associate Director, DMPK & Modeling Takeda Pharmaceutical
Seminars
Wednesday 14th October 2026
Beyond Allometry: Assessing Translational PK/PD Modeling for Human Projection of a Nonlinear Immune Cell Directed ADC
2:30 pm
- Highlighting the translational uncertainty of nonlinear, target mediated ADC PK in first-in human prediction
- Integrating preclinical ADC data and clinical data points from parental antibody to improve accuracy of translation
- Leveraging population PK/RO simulations to inform TAK-500 human exposure, receptor occupancy, and pharmacologically active dose selection
