Manish Hudlikar
Associate Principal Scientist Merck & Co
Seminars
Wednesday 14th October 2026
Harnessing Computational & Mechanistic Insights Into Chemoselective Reduction for Engineered Cysteine Site-Specific ADCs
11:00 am
- Laying out experimental work to develop a novel conjugation method utilizing chemoselective reduction of engineered cysteines, with broad site-specific conjugation applicability
- Utilizing computational modeling to visualize conjugation sites shielded during circulation
- Identifying optimized conjugation sites by combining insights from x-ray crystallography structures
