Manish Hudlikar
Associate Principal Scientist Merck & Co
Manish Hudlikar is an Associate Principal Scientist in Discovery Chemistry and ADCs at Merck & Co., where he leads the design and development of next-generation ADCs and bioconjugates. A strategic drug discovery scientist, Manish specializes in translating innovative synthetic organic and bioconjugation chemistry into clinical assets. His work spans novel payloads, including cytotoxins, protein degraders, and antisense oligonucleotides, with experience advancing programs from early discovery through late-stage development. He is passionate about bridging cutting-edge chemistry with impactful medicines for patients.
Seminars
Wednesday 14th October 2026
Harnessing Computational & Mechanistic Insights Into Chemoselective Reduction for Engineered Cysteine Site-Specific ADCs
11:00 am
- Laying out experimental work to develop a novel conjugation method utilizing chemoselective reduction of engineered cysteines, with broad site-specific conjugation applicability
- Utilizing computational modeling to visualize conjugation sites shielded during circulation
- Identifying optimized conjugation sites by combining insights from x-ray crystallography structures
