Marica Speranza
Senior Scientific Director, Innovation, Extracellular Targeted Cancer Therapeutics Research Unit GlaxoSmithKline
Seminars
Monday 12th October 2026
Assessing the Demand for & Strategy to Identify & Optimize Dual Payload ADC Combinations to Combat Classical Cytotoxic Resistance Mechanisms
12:00 pm
- Contextualizing the need for novel payloads and payload combinations to circumvent resistance mechanisms to Topo1 and other classical payloads
- Breaking down a rationale-driven approach for novel payload combinations beyond dual cytotoxics
- Laying out preclinical approaches to identify and optimize dual payload combinations to set up translation for success
