Peng Guo
Professor Hangzhou Institute of Medicine, Chinese Academy of Sciences
Dr. Peng Guo is a principal investigator at the Hangzhou Institute of Medicine, Chinese Academy of Sciences, specializing in vascular biology and advanced drug delivery systems. His work centers on how healthy and malignant vasculature responds to complexes such as ADCs. Dr. Guo has authored several influential ADC studies, including breakthroughs in HER2 targeting ADC bystander activity, ICAM1 directed ADCs for refractory cancers, and epigenetic reprogramming strategies that enhance ADC efficacy. His lab integrates AI driven target discovery with bio inspired delivery technologies to advance next generation oncology therapeutics.
Seminars
- Explaining rationale for combining a HER2 ADC with trastuzumab
- Describing preclinical and clinical results of combination trials, highlighting clinical benefit of ADC antibody combinations
- Investigating mechanism to understand how antibody combination helps ADC overcome binding site barrier to improve tumor penetration and improve efficacy