Ragoo Raghunathan
Vice President, Global Commercial VivoSim Labs, Inc.
Seminars
Monday 12th October 2026
Resolving ADC Liver & GI Toxicity in Human 3D Tissue: Separating mAb, Linker & Payload Contributions Before Animal Studies
12:30 pm
- Contextualizing the liver and GI translational gap for ADCs and where human 3D models fit into hit-to-lead screening, candidate nomination, and on-demand investigative toxicology
- Establishing a reference benchmark from small-molecule datasets so ADC results are read against a clinically anchored reference set
- Investigating case studies deconstructing ADC toxicity to its components in human tissue, with side-by-side data showcasing findings that a single gut model would miss
