Assessing Immunogenic Senescence to Promote the Activity of Topo1 Inhibitor ADCs

  • Exploring how Topo1 and Topo1 ADCs elicit immunogenic cell stress in vivo through the induction of cellular senescence
  • Delineating the host immune cell requirements for Topo1-induced immunogenicity
  • Identifying biomarkers of immunogenic cell stress mediated by Topo1 ADCs