Beyond Allometry: Assessing Translational PK/PD Modeling for Human Projection of a Nonlinear Immune Cell Directed ADC

• Highlighting the translational uncertainty of nonlinear, target mediated ADC PK in first-in human prediction
• Integrating preclinical ADC data and clinical data points from parental antibody to improve accuracy of translation
• Leveraging population PK/RO simulations to inform TAK-500 human exposure, receptor occupancy, and pharmacologically active dose selection

Speakers:

Konstantin Piatkov

Associate Director, DMPK & Modeling

Takeda Pharmaceutical