From Internalization to In Vivo Performance: Exploring Mechanistic Insights from Two Marketed ADCs

• Comparing two marketed ADCs with regard to their stability, internalization, payload release mechanism, and ADME to help explain differences in efficacy and toxicity observed in the clinic
• Leveraging Cryo-EM and molecular dynamic simulations to provide atomic-level insights into the structural mechanisms underlying these differences

Speakers:

Hua Yang

Chief Scientific Officer

Pharmaron