Contrasting Discovery & Preclinical Head-to-Head Comparison of Two ADCs
- Leveraging fully integrated ADC platform to enable comprehensive discovery and preclinical characterization
- Directly comparing SG and Dato-DXd with pH-sensitive and protease-specific linkers • Assessing how linker-driven payload release influences efficacy, in vitro and in vivo bystander effects, dosing and safety
- Completing physicochemical, structural, in vitro, in vivo, DMPK and toxicology assessments