Exploring Next-Generation High DAR Dual Payload ADCs Featuring Novel Payloads to Enhance Efficacy, Overcome Resistance & Improve Safety

12:30 pm - Monday 12th October 2026

  • Leveraging a cutting-edge cell free platform and novel payload classes to discover high-DAR dual payload ADCs aimed at overcoming resistance to single payload ADCs
  • Demonstrating synergistic efficacy of Topo1-based combinations with diverse mechanisms, including DDR inhibitors, to enhance anti-tumor activity
  • Validating improved preclinical efficacy of dual payload ADCs across in vitro and in vivo/PDX models to support their potential in resistant tumor settings

Speakers:

Senior Director, Chemistry
Sutro Biopharma