Harnessing X-Ray Crystallography & Novel Method Methodology to Selectively Reduce Conjugate ADC Payloads
- Unveiling x-ray crystallography ADC structures to visualize linker-payload sites shielded during ADC circulation
- Developing a methodology to directly reduce engineered disulfide bonds and avoid side products through interchain disulfide bond oxidation
- Laying out method applications for any payload, including sitespecific conjugation for dual payload ADCs