Melissa Schutten
Seminars
Thursday 15th October 2026
Translating ADC Tolerability: Deep-Diving Into Toxicity Characterization & Preclinical Strategy to Better Predict ADC Clinical Safety Profiles
9:00 am
Even with 2026 seeing ADCs continue to rival oncology standard of care performance, translation of ADC toxicity profiles to the clinic remains the largest hurdle to widen ADC therapeutic index and accomplish widespread impact for patients in need.
Led by long-standing ADC toxicity experts, join your peers to understand ADC class effect toxicities and best leverage preclinical tools and historical learnings to effectively characterize safety profiles and predict ADC tolerability in the clinic.
Workshop highlights include:
- Discussing ADC class effect toxicities observed in the clinic across ocular toxicity, ILD, neutropenia and beyond
- Delving into deployment and utilization of in vivo and in vitro models to improve prediction of clinical toxicity profiles
- Breaking down lessons learned from successful and failed historical ADC translation to inform design, engineering and characterization of better ADCs with wider therapeutic index