Jiang Liu
Executive Director, Molecular Oncology Aarvik Therapeutics
Seminars
Monday 12th October 2026
Developing Hydrophilic ADCs via Engineering Novel Short Linkers & Antibody Conjugation Sites
12:30 pm
- Linker Engineering: Introducing AQUALINK platform utilizing simple sugar groups as a spacer to engineer hydrophilic ADCs
- Antibody Engineering: Identifying unique conjugation sites that can shield around the hydrophobic payload to result in overall hydrophilicity to the ADC
- Breaking down novel hydrophobic ADCs In vitro and in vivo data to demonstrate differentiation from conventional ADCs
