Travis Biechele
Vice President & Head of Research Shasqi Inc.
Seminars
Monday 3rd November 2025
Understanding Driving Factors & Exploring Opportunities to Overcome Off- Target Toxicities to Improve ADC Safety & Efficacy
10:00 am
- Understanding driving factors of off-target toxicities and widespread impact on ADC clinical efficacy profiles
- Highlighting the need for novel methods of ADC tumor targeting to combat ADC off-target toxicity, including the use of pre-targeting
- Sharing pre-targeting data from CECAM5 program that separates binder from payload and uses click chemistry to reunite them at the tumor, highlighting differentiated efficacy and safety
