Day One

• Introducing the multi-faceted MUTTA platform to develop multi-epitope targeting tetravalent ADCs
• Leveraging MUTTA platform to expand development of differentiated dual targeting ADCs, screening over 50 unique target pairs to identify >15 novel dual targeting MUTTA ADCs
• Presenting preclinical data on several programs including the dual targeting MUC16 and NaPi2b ADC (AV-P138-ADC/ ARR-002)

• Navigating the complexities of ADC development from challenges in target selection and patient stratification to understanding resistance mechanisms
• Discovering how Tempus’ integrated platform uses multimodal real-world data, AI, and patient-derived organoids to help inform development strategies and support patient population identification
• Exploring how an established diagnostic engine and a connected oncologist network can help facilitate ADC adoption and support a streamlined path to commercialization

• Delving into the IND enabling profiles of bispecific ADCs NEOK001 and 002, emphasizing advantages over monospecific ADCs
• Explaining the unique characteristics of NEOK001 targeting B7-H3+ROR1 including higher need for differentiation amongst B7-H3 ADC landscape
• Breaking down early clinical development strategy and lessons learned from ongoing Phase I bispecific ADC trials

• Leveraging RenLite common light chain to eliminate mismatching, ensuring high homogeneity and “antibody like” stability for complex dual payload formats
• Combining two distinct, complementary MoAs on a single molecule to tackle tumor heterogeneity and bypass resistance
• The RenSuper Workstation AI Platform scans 200+ TAA targets and hundreds of thousands of ready-to go antibodies to match the ideal lead with optimal internalization in record time

• Contextualizing Auristatin-S ADC development given tolerability-led narrow therapeutic index from historical clinical ADCs
• Delving into CDX and PDX data highlighting equivalent efficacy profile with improved tolerability and bystander activity
• Breaking down the opportunity of Auristatin-S ADC to be administered at higher dose and deliver clinical benefit melanoma, head and neck, esophageal and NSCLC

• Addressing challenges of tumor heterogeneity and poor drug penetration of solid tumors with internalization independent payload release
• Screening and identifying a unique linker using a specific TME enzyme consistently expressed across cancer models for next-generation ADC development
• Achieving superior efficacy and safety with an internalization independent linker-payload system in ductal carcinoma and squamous carcinoma cell lines 

• Outlining design and development of STRO-006, an integrin beta-6 targeted DAR8 Topo1 ADC
• Evaluating STRO-006 in a PDX clinical trial to identify biomarkers correlating with response
• Undergoing translational workstreams to enable successful clinical development 

• Assessing ADC efficacy through in vitro PDXO, MiniPDX, and PDX models
• Establishing a unique panel of PDX models to reveal resistance driven by payload mechanism, independent of the target antigen
• Validating rational combinations including ADC+IO to overcome immunosuppressive resistance
• Informing the design of bispecific or dual payload ADCs, engineered to circumvent resistance pathways

• Laying out rationale for pursuing less toxic ADC development to enable higher dosing and expand ADC therapeutic index
• Breaking down late-stage preclinical data of KIVU-107 in solid tumors to emphasize clinical opportunity and differentiation strategy
• Unveiling the emerging clinical profile of KIVU-107 to investigate how well preclinical data translates to patient responses and lay out ongoing clinical development strategy

• Discussing how site specific ConjuAll platform enables discrete DAR ADCs with circulation stable bioconjugation
• Leveraging proprietary beta glucuronidase technology to enable unprecedented preclinical therapeutic indexes through tumor selective release and payload activation
• Assessing early clinical safety and efficacy across payload classes to validate the LCB platform

• Contextualizing suboptimal MUC1-N targeting properties to demonstrate benefits to MUC1-C subunit as an ADC target
• Exploring preclinical PDX safety and efficacy for XYA01/02 leading to NCI NExT program selection and IND enabling development
• Evaluating XYA01/02 trial design positioning for differentiated impact across MUC1-C-expressing epithelial carcinomas versus existing anti-MUC1 ADCs

This is your opportunity to present newly published first in-human and Phase I clinical data in front of our specialized audience of industry experts. Data must be published and available to be presented ahead of the deadline of Friday, September 4. Email info@hansonwade.com to register your interest.

• Exploring trends and updates from preclinical and clinical ADC development • Reviewing key highlights for ADC innovation and development in 2025 and 2026
• Examining emerging ADC approaches including dual payloads, bispecific ADCs and DACs
• Visualizing the history of ADC development, giving perspective on how far the ADC space has come and where it is heading

• Accessing unique patient populations and enriching enrollment with those more likely to relapse with a comprehensive biomarker approach that integrates CGP, MRD, multi-omics, and RWD
• Detecting molecular response within weeks of therapy initiation and identifying which patients are benefiting
• Enhancing clinical development and trial designs by using ctDNA for response monitoring to allow for earlier efficacy readouts and as an early surrogate endpoint to support regulatory conversations

• Laying out the history and progress made developing ADCs and other therapeutics against c-Met
• Detailing the safety and efficacy profile of ABBV-400, focused on CRC and solid tumor indications
• Exploring future development plans and potential of ABBV 400 in impact CRC patients currently underserved by ADC therapies

This is your opportunity to present newly published first-in human and Phase I or beyond clinical data in front of our specialized audience of industry experts. Data must be published and available to be presented ahead of the deadline of Friday, September 4. Email info@hansonwade.com to register your interest.

• Leveraging HPLC with automatic probe sampling to understand process chemistries including conjugation and reduction kinetics
• Investigating applications of automatic data analysis across multiple stages of ADC process development
• Highlighting proof-of-concept for ADC process automation and ongoing use case

• Exploring the differing development approaches of ADCs across the preclinical to commercial spectrum
• Understanding how the bioconjugate landscape now encompasses a wide variety of modalities with differing MoAs and molecular structures
• Exploring relevant examples of how the requirements for process and analytical development can vary between different conjugates

• Highlighting the necessity to leverage high throughput methods and automation to accelerate ADC process and analytical characterization
• Laying out methodology is incorporate automation in PAT and increases platform throughput in ADC development
• Understanding high throughput methods for process monitoring and real time bioconjugation approaches

• Discussing an integrated platform approach that utilizes real-time PAT, engineering principles, and strategic methodologies
• Outlining strategies for optimizing conjugation chemistry and dual payload conjugates
• Exploring case studies to demonstrate how this approach enhances decision making, reduces timelines, and improves cost efficiencies in the ADC pipeline

• Exploring CMC projects to enable time, cost and sustainability-sensitive ADC manufacturing
• Contextualizing CMC strategy from a portfolio lens to manage CMC across multiple global ADC programs
• Understanding how to plan and adapt CMC approaches to accommodate for future ADC product launches without compromising manufacturing quality, cost and timelines 

• Exploring quantitative risk and exposure assessment development of occupational exposure limits, acceptable surface limits and permitted daily exposures
• Undergoing quantitative exposure assessment for worker exposure purposes including validated industrial hygiene air sampling and surface sampling methods
• Reviewing extractables and leachables for bioprocess train and container closure systems for patient safety 

• Exploring an AI-enabled, modular, antibody-agnostic linker platform to enable reproducible manufacturing of scalable dual payload ADCs
• Laying out considerations for rapid development and manufacturing of novel dual payload ADCs while maintaining cost efficiency comparable to single payload ADCs
• Demonstrating proven manufacturability and developability across multiple dual-payload ADCs

• Overviewing the challenges in bioconjugation CMC development for novel NDCs
• Case study examples: Exploring strategies and fit for purpose solutions for complex bioconjugation processes development
• Overviewing AsymChem/ AsymBio’s integrated capabilities in NDC CDMO services