POST-CONFERENCE WORKSHOP DAY
Thursday | November 7, 2024
8:00 am Check In, Morning Coffee & Refreshments
For Beginners in the ADC Field
Workshop A
The Chemistry & Properties of Antibody-Drug Conjugates: Linkers, Toxins & Their Effect on Therapeutic Index
Overviewing different classes of payloads and linker technologies employed by ADCs
Analyzing the synthetic challenges in preparation of linker-payload constructs and reactive groups necessary for attachment and release
Discussing the pros and cons of existing conjugation technologies.
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Session Presented By NJ BIO
For Everyone in the ADC Field
Workshop D
Breaking Down Different ADC Design & Component Contributions to Set Up ADC Development for Success
Showcasing ADC case studies and designs tackling the same target - are there multiple pathways and designs to achieve success against the same targets?
Breaking down insights gained from recent ADC clinical trials Characterizing individual competent contributions as well as how all component work as a whole
Debating the valuable takeaways from different approaches to the same target
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Robert Lutz, Chief Scientific Officer, Iksuda Therapeutics
Jutta Deckert, Vice President, Research & Development, Iksuda Therapeutics
12:00 pm Check In, Morning Coffee & Refreshments
For Beginners in the ADC Field
Workshop F
Delving Into the Chemistry & Art of ADC Linkers & Understanding Significance & Applications on ADC Properties & Performance
Linker chemistry 101: breaking down the current state of the science behind ADC linkers – bringing the chemistry to those designing and intending to design the ADCs
Contextualizing and processing linker data seen in literature and tackling a uniform linker nomenclature
Hearing case study examples of best linker technology currently under development and discussing the methodology of assessing performance
Breaking down the benefits and challenges of how best to leverage these as guidance in your ADC design
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Paul Davis, Independent
For Everyone in the ADC Field
Workshop I
Using Computational Approaches for Early-Stage Design & Late-Stage Development of Antibody Drug Conjugates
Exploring the multiscale mechanisms of ADC distribution, from subcellular to cellular, tissue, organ, and systemic biodistribution
Discussing the (sometimes) counterintuitive results of ADC efficacy in animals and the clinic
Reviewing the practical implementation of an ADC simulator to predict how ADC design impacts efficacy
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Greg Thurber, Associate Professor & Chair, Graduate Education, University of Michigan