Harnessing Computational & Mechanistic Insights Into Chemoselective Reduction for Engineered Cysteine Site-Specific ADCs
- Laying out experimental work to develop a novel conjugation method utilizing chemoselective reduction of engineered cysteines, with broad site-specific conjugation applicability
- Utilizing computational modeling to visualize conjugation sites shielded during circulation
- Identifying optimized conjugation sites by combining insights from x-ray crystallography structures