Scientific Program - Day 1
Thursday October, 10

Honorary Chair

Dedicating over 30+ years to ADC drug development and attending every World ADC we’re delighted to be welcoming John as our Honorary Chair

John Lambert
Executive Vice President, Emeritus &
Distinguished Fellow


Chair’s Opening Remarks

Rich Gregory
Chief Scientific Officer


Keynote: Celebrating 10 Years of World ADC- How far the Field Has Come & Where we are Going

• Ten years ago, there was only one marketed ADC, MylotargTM, that was approved in 2000. However, within one year of the first World ADC meeting, MylotargTM was withdrawn from the US and EU markets following a failed phase 3 trial
• However, the approvals of AdcetrisTM (in 2011 for HL and ALCL) and KadcylaTM (in 2013 for HER2+ metastatic breast cancer), two ADCs utilizing potent tubulin agents as payloads, re-ignited enthusiasm for using antibodies for targeted delivery of cytotoxic agents to cancer tissue. In 2017, MylotargTM was re-approved for treatment of AML, and another calicheamicin conjugate, BesponsaTM, received approval for treating B-ALL
• Today, KadclyaTM sales exceed $1 billion annually. There are more than 83 different ADCs currently in clinical development. While there are many factors to ensuring the creation on a successful ADC (right target, right antibody, right linker properties and attachment site(s), right payload), getting it right can create ADCs that can become important medicines for treating human disease (especially cancer)

John Lambert
Executive Vice President, Emeritus &
Distinguished Fellow


Keynote: Learning from Failures & Enabling Innovations in ADCs to Fight Against Deadly Cancers

• What is common among clinically successful ADCs?
• What went wrong with some clinically unsuccessful ADCs?
• Top five lessons learned from the development of ADCs in the last two decades
• Next Generation ADCs meeting the five rights

Rakesh Dixit
President & Chief Executive Officer


Speed Networking

This session is a great opportunity to introduce yourself to the attendees that you would like to have more in depth conversations
with. This session is the ideal opportunity to get face-to-face time with many of the brightest minds working in the ADC field and
establish meaningful business relationships.


Morning Refreshments

Clinical Stream

Confirmed Chair:

Sri Ghatta, Director & Clinical Scientist, Genmab 

CMC Stream

Confirmed Chair:

Lisa McDermott, Head of Process & Analytical Development ,
Millipore Sigma

Discovery Stream

Confirmed Chair:

Peter Senter, Vice President & Distinguished Research Fellow, Seattle Genetics

Translational Stream

Confirmed Chair:

Gail Lewis Phillips, Senior Scientist - Translational Oncology, Genentech

Operational Lessons Learned from Phase I Studies & Failures

Exploring Methods to Improve Scalability & Capacity of Manufacturing Processes

Understanding the Relationship Between Payload, Linker & Antibody to Increase Efficacy

Using DMPK Modelling to Mitigate Toxicities


Reviewing the ADC Clinical Pipeline

• Update on the key movements in the clinic
• Insight into the rapidly evolving pipeline
• Analysis of novel clinical ADCs

Letrishka Anthony, Senior Analyst, Beacon Targeted Therapies, Hanson Wade


Key CMC Considerations for Robust ADC Process Development & How to Effectively Manage the CMC Supply Chain

• Delve into the unique technical challenges of ADC process development
• Share experiences on how to confidently manage the complexity in ADC supply chains
• Discuss insights on how to transfer ADC processes to cGMP manufacture

Eric Lacoste, Head of Bio-Organic Team & Chemistry, Manufacturing, Control & Project Manager, Sanof


Site-Specific Antibody-Drug Conjugates Carrying Multiple Drugs per Cysteine Conjugation Site

• A novel cysteine-based conjugation platform for the preparation of site-specific high drug load per cysteine conjugation site is presented
• This entails site-specific antibody drug conjugates carrying multiple drugs per cysteine conjugation site

Nazzareno Dimasi, Associate Director Research & Development, AstraZeneca


Discussing Strategies to Tailor the Molecular Design & PKPD Based on Various Properties of the ADC

• Determinants of ADC distribution
• Quantitative systems pharmacology (QSP) and ADC PK/PD
• Rational ADC design via QSP

Mark Stroh, Clinical Pharmacology, CytomX


Phase 1 Study of ABBV-085, an Antibody-Drug Conjugate Targeting LRRC15, in Sarcomas & Other Advanced Solid Tumors

• LRRC15 target identification and biological relevance in cancer
• ABBV-085, a LRRC15 targeting optimized MMAE (auristatin) ADC
• Phase 1 clinical trial design, escalation and expansion cohort data
• Clinical safety and efficacy observations from the completed Phase 1

James Purcell, Senior Scientist & Program Director, Oncology, AbbVie


Giorgio Salciarini, Technical Business Development Manager, BSP


ThioBridge™ as a Tool for the Design, Optimization & Manufacture of ADCs

• ThioBridge™ conjugation is a flexible approach for producing stable ADCs with defined location and extent of drug loading
• The simple design of ThioBridge™ ADCs means they can easily undergo a systematic determination and optimization of their in vitro and in vivo biological properties
• ThioBridge™ targets natural disulfides with highly reproducible conjugation profiles at milligram to gram scales
• Abzena’s capabilities for design, optimization and manufacturing of ADCs

Mark Frigerio, Director Chemistry, Abzena


Assessing Methods To Use For Understanding How You Know Your Drug Is Working

Session reserved


Development of AVID100, an AntiEGFR ADC with a Novel Mechanism for Tumor Selective Cytotoxicity

• AVID100 is being evaluated in Phase 2a dose-expansion cohorts of patients with EGFR-overexpressing SCCHN, sqNSCLC, and TNBC
• AVID100 is highly potent and selectively cytotoxic against EGFR-expressing cancer cells, while sparing normal EGFRpositive keratinocytes
• AVID100 effectively inhibits tumor growth in mouse xenograft studies across a variety of a cancer types
• AVID100 was well-tolerated in a Phase 1a dose-escalation trial in patients with advanced solid tumors with only modest skin toxicity observed

Maureen O'Connor, Chief Scientific Officer, Forbius


Sharing Common Manufacturing & Molecular Misconceptions

• It is important to survey this data for generalizations and guidelines to accelerate development of promising new candidates, oversimplification of experimental findings can lead to misunderstanding that compromises drug development
• In addition, the body of knowledge that has accumulated around ADCs puts us in a position to question portions of the testing paradigm that were put in place in the absence of such data. Some such questions will be posed for discussion

Damon Meyer, Associate Director, Conjugation Process Development, Seattle Genetics


Exploring Novel Lower Potency PBD Payloads

• Next generation PBD payloads
• Warhead optimisation
• Exploring the effect of N10 Capping groups

Philip Howard, Chief Scientific Officer, Spirogen


Analyzing the Clinical Development of STRO-001 & STRO-002

• Review preclinical and IND enabling data for STRO-001 and STRO-002, two novel ADCs generated with cell-free protein synthesis and site-specific conjugation technology
• Provide clinical development update for STRO-001 for treatment of myeloma and B-cell lymphoma
• Deliver clinical development update for STRO-002 for treatment of ovarian cancer

Arturo Molina, Chief Medical Officer, Sutro Bio


Targeting CD205-positive Solid Tumors with a Novel Antibody Drug Conjugate to Reverse Immune Tolerance

• OBT076 includes a fully human antibody targeting CD205, which is overexpressed in subsets of Her2 negative cancer
• In addition to HER2 negative breast cancer, the investigational agent is being developed for a number of other CD205 driven cancers such as gastric cancer, triple-negative metastatic breast cancer, bladder cancer and pancreatic cancers as well as Non-Hodgkin Lymphoma and several other solid and liquid cancers

Christian Rohlff, Chief Executive Officer, Oxford Biotherapeutics


Reviewing Strategies for a Smooth Transfer & Scale-up at a CDMO

• Explore services and methods for smooth ADC transfer and scale-up
• Analytical strategies for ADC development
• Confidently characterize ADC properties

Melanie Derde, Bioconjugation Analytics Manager, Novasep


Exploring an Enhanced Single Molecule PEG for ADC Linker
















12.15 Extended Q&A


Panel Discussion: Utilising PKPD Studies to Their Full Potential to Confidently Translate into the Clinic

• Discuss which studies are best to use
• How these studies can be utilized to improve preclinical to clinical translation
• Review the lessons learned to enhance confidence in translation


Lunch & Networking


Sartorius Lunch Seminar: Platform Strategies to Accelerate ADC Process Development & De-Risk Manufacturing using Single Use Technologies – Case Studies will be Presented

Ian Schwartz
Global Bioconjugation Technology Consultant
Sartorius Stedium Biotech

Operational Challenges in Clinical Trials & Innovations to Overcome This

Ensuring an Efficient Supply Chain Process

Delving into Innovative Technologies for Payloads & Linkers

Sharing Strategies to Advance Preclinical Development


Ligand Targeted Cancer Therapy: A Tactical Swing from Chemo to Radiotherapy

• Brief development history of small molecule drug conjugates (SMDCs)
• Comparison of targeted chemo vs. radioligand therapy
• Overview of 177Lu-PSMA-617 and next generation RLTs

Chris Leamon, Vice President, Research, Endocyte


Creating & Sticking to a Time Efficient Supply Chain Process

Sabra Hanspal, Senior Scientist, AbbVie CMO


Discovering Various Payload-Linker Combinations for Optimized Efficacy

• Payload and linker-payload design
• In vitro screening of payloads and ADCs
• Confidently assess ADC in vivo efficacy

Thomas Nittoli, Research & Development, Regeneron


Modifying an Old Platform to Identify New ADC Targets

• Tumor specific human antibodies were identified by panning on tumor cells isolated by laser capture microdissection. Rapidly internalizing antibodies were identified using HCA assays
• Lead candidate antibodies were used to identify a promising new target in mCRPC and Multiple Myeloma
• A vc-MMAE antibody conjugate was developed (FOR46) and patients are currently being dosed at multiple clinical sites

Marc Nasoff, Chief Scientific Officer, Fortis Therapeutics


Therapeutic Targeting of Prostate-Specific Membrane Antigen (PSMA)

• Differences in radionuclide vs drug payloads
• Differences in targeting vehicles: antibody vs small molecules
• Is there a need for treatment selection by target expression?

Scott Tagawa, Associate Professor in Hematology, Oncology, Clinical Medicine & Urology Weill Cornell - Cornell University


Aligning the Complex ADC Supply Network to Make Drug Products for Patients

• Strategies for supply network alignment
• Identification of risks in the supply chain

Praveen Prasanna, Director, External Manufacturing, ImmunoGen


Homogeneous Antibody Functionalization Via Orthogonally Reactive Lysine & Arginine Residues In One Step & One Pot

• We describe a new blend of chemistry and biology by developing the first site-specific antibody conjugation technology that employs an engineered arginine residue. We achieved this by replacing a uniquely reactive lysine residue at the bottom of a deep pocket that forms the active site of a catalytic antibody with an arginine residue and by demonstrating that the ensuing uniquely reactive arginine residue can be selectively conjugated to various phenylglyoxal derivatives
• The distinctive arginine and lysine residues can be combined in one antibody molecule to afford orthogonal conjugation of two different cargos with high precision and efficiency under mild conditions in a one-step and one-pot reactione Step and One Pot

Christoph Rader, Associate Professor, Department of Immunology & Microbiology, The Scripps Research Institute


Innovating Late Stage Pre-Clinical

Studies Session Reserved


Tisotumab Vedotin: Update from Clinical Study InnovaTV 201

• Tisotumab vedotin`s (TV) early clinical studies
• Data from Cervical cancer cohort of InnovaTV201
• Ocular adverse events mitigation plan and data from InnovaTV201

Sri Ghatta, Director & Clinical Scientist, GenMab


Value Proposition of Integrated, Advanced ADC Manufacturing Processes – Use of Economic Modelling

Session Reserved


TrypCo® Technology: A Versatile Enzymatic Tool for Sitespecific Generation of ADC’s

• Introduction into BTI´s novel TrypCo® technology as robust conjugation platform for the enzyme-based generation of sitespecific ADC´s
• POC studies for the N- and C-terminal modification of Trastuzumab will be presented
• High flexibility of TrypCo® enables orthogonal dual modification of antibodies and their fragments

Andreas Simon, Chief Technology Officer, BTI


Synergistic Combinations of ADCs & Small Molecules that have Potential for Clinical Implementation

• ADCs have failed to meet expectations of single-agent efficacy in clinical settings. To expand their therapeutic index and augment ADC impact, we sought to identify small molecule synergies with ADC payloads to guide strategies in clinical therapy
• Develop a method for in vitro highthroughput screening of small molecule combinations in 1,536-well plates. The workflow is amenable to diverse solvents, enabling the future study of bio therapeutics and small molecules
• Screen a 2,400-compound, oncology focused and annotated library in combination with common ADC payloads and identified synergistic pairings determined by the Bliss synergy metric

Jacob Roth, Research Fellow, National Centre for Advancing Translational Sciences


Scientific Poster Session & Afternoon Refreshments

The Poster Session is an informal part of the conference agenda, allowing you to connect with your peers in a relaxed atmosphere and continue to forge new and existing relationships. During this session over 60 scientific posters will be presented from novel linker designs to validation of site specific conjugation technologies and more informative in vivo models.

Uncovering the Wave of Next Generation Successful ADCs


“Light Path” – Leveraging Lonza’s Experience with Timelines & Cost Reduction of Bioconjugate Drug Substance Supply

• Discover Lonza’s ADC capabilities and learn about future capacity increases at the manufacturing site in Switzerland
• Roll-out of a novel ADC manufacturing offer/concept for customers: BioConjugates LightPath Development
• Fast generation of ADC drug substance for to support clinical phase I trials. Utilization of Lonza’s bioconjugation experience to reduce customer effort to a minimum and accelerate project timelines

Patrick Dennler
Lab Head / Scientific Specialist


ZW49 A Bispecific HER2-targeted ADC: Next Generation ADC Combining Azymetric & ZymeLink Platforms

• Discuss ZW49, a biparatopic antibody-drug conjugate armed with our proprietary ZymeLink™ cytotoxic payload

In vivo efficacy compared to approved and leading clinical-stage HER2-targeted ADCs
• GLP toxicology studies predict an enhanced therapeutic window enabling extended dosing in the clinic

Tony Polverino
Chief Scientific Officer


Development of a Novel Chemical Site-Specific ADC Conjugation Platform with Enhanced Therapeutic Window

• The chemical conjugation of antibodies in a site-directed manner remains an area of great interest and active efforts within the ADC community are being made
• Overcome the lack of sensitivity that can be dialled in toward specific residue during the chemical modification
• Analyze a new platform for the site-selective conjugation of antibodies through the use of a novel class of IgG Fc-affinity peptide reagents to install payload-compatible linkers to well-defined amino acid residues. The activity of these resulting DAR2 ADCs
will be reviewed and assessed compared to the state-of-the-art

Brian Mendelsohn
Ajinomoto Biopharma Services


Chair’s Closing Remarks

Rich Gregory
Chief Scientific Officer